Karenliu
The Liu Lab | Department of Craniofacial Biology | Kings College London |
Home | Research | Publications | Protocols & Etc. | Lab Members | Contact Us | Links |
Welcome to the Liu Lab!
We are interested in signal transduction in developmental biology.
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
<wikionly>
Recent updates to the lab wiki
- N
- This edit created a new page (also see list of new pages)
- m
- This is a minor edit
- b
- This edit was performed by a bot
- (±123)
- The page size changed by this number of bytes
28 April 2024
|
17:40 | Multilayer Paper Microfluidics - Madyson Redder 9 changes history +495 [Mredder (9×)] | |||
|
17:40 (cur | prev) −25 Mredder talk contribs (→Wildlife and Habitat Conservation) | ||||
|
17:40 (cur | prev) −25 Mredder talk contribs (→Pharmaceutical Industry) | ||||
|
17:39 (cur | prev) −18 Mredder talk contribs (→Developing Countries and Travel) | ||||
|
17:39 (cur | prev) −23 Mredder talk contribs (→Origami Folding) | ||||
|
17:38 (cur | prev) −25 Mredder talk contribs (→Paper Stacking) | ||||
|
17:09 (cur | prev) −9 Mredder talk contribs (→Developing Countries and Travel) | ||||
|
17:08 (cur | prev) −2 Mredder talk contribs (→Pharmaceutical Industry) | ||||
|
17:08 (cur | prev) +316 Mredder talk contribs (→Pharmaceutical Industry) | ||||
|
17:07 (cur | prev) +306 Mredder talk contribs (→Pharmaceutical Industry) |
|
17:30 | Nanoimprint Lithography (NIL) - Carter Paul 14 changes history +1,132 [CarterPaul (14×)] | |||
|
17:30 (cur | prev) 0 CarterPaul talk contribs | ||||
|
17:24 (cur | prev) +58 CarterPaul talk contribs | ||||
|
17:23 (cur | prev) −3 CarterPaul talk contribs | ||||
|
17:22 (cur | prev) +11 CarterPaul talk contribs | ||||
|
17:22 (cur | prev) +519 CarterPaul talk contribs (→Roll-to-roll NIL Fabrication Example) | ||||
|
17:11 (cur | prev) +10 CarterPaul talk contribs (→References) | ||||
|
17:11 (cur | prev) −10 CarterPaul talk contribs (→Ultraviolet (UV) NIL and Machining Mechanism) | ||||
|
17:11 (cur | prev) +6 CarterPaul talk contribs | ||||
|
17:10 (cur | prev) +92 CarterPaul talk contribs | ||||
|
17:07 (cur | prev) +119 CarterPaul talk contribs (→Ultraviolet (UV) NIL and Machining Mechanism) | ||||
|
17:03 (cur | prev) +325 CarterPaul talk contribs (→References) | ||||
|
16:59 (cur | prev) −3 CarterPaul talk contribs | ||||
|
16:58 (cur | prev) +8 CarterPaul talk contribs | ||||
|
16:58 (cur | prev) 0 CarterPaul talk contribs |
17:01 | Microfluidics for DNA Sequencing - Khiem Le diffhist +3 Khiemle talk contribs (→Microdroplet-Based Technology) |
17:01 | Upload log Khiemle talk contribs uploaded a new version of File:Microfluidic DNA Sequencing - Source 7.png |
<nonwikionly> This page was created using Open Wetware.</nonwikionly>